Sucralose has been proven to worsen diabetes, abort pregnancies, and toxify the liver and kidneys. These are unmistakable signs that sucralose is an extremely dangerous substance, but it is the least-studied artificial sweetener. It is one of the more recent sweeteners from the diet industry. One of the reasons for sucralose's fast-track approval is because aspartame cannot be used in baked foods, for it breaks down at high temperatures into toxic substances, as it does during metabolisis within the human body. Sucralose was hailed to be a better alternative for cooking, but it releases chloropropanols when heated, which are toxic chlorine byproducts.
A 2008 study by Duke University titled, Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats, showed that sucralose reduces the amount of beneficial bacteria (flora) in the gastrointestinal tract, and through this action; it is a suspected cause of inflammatory bowel disease. The same study showed that it inhibited the absorption of "orally administered drugs". Sucralose therefore impairs the gastrointestinal system to cause malnutrition. Significant weight and health issues will manifest themselves, since the malnutrition will activate starvation hormones that can take decades to turn off. As a result, both dietary problems and disease states can be expected to become grossly exaggerated.
The makers of Splenda, McNeil Nutritionals, were sued by the Sugar Association, in response to McNeil's dishonest marketing campaign: "Made from sugar, so it tastes like sugar". Sucralose is actually a toxic chemical compound that is synthesized by combining sugar (sucrose) with chlorine to produce something unique. The lawsuit was settled out of court, and the makers of sucralose have discontinued implying that their product is similar to real sugar in taste, substance, or safety.
A report published by the National Institutes of Health stated that sucralose is mutagenic (DNA altering), and that it furthermore induces lymphoma (lymphatic cancers) in mice. The report is somewhat ironic, since the National Institutes of Health is the sister organization of the F.D.A., which has been blessing Splenda for years and doing damage control for its manufacturer.
Aspartame (NutraSweet and Equal)
The California Environmental Protection Agency recently urged independent scientists to conduct new animal studies to further expose the link between aspartame and cancers. In 2005, researchers at the Ramazzini Foundation in Bologna, Italy conducted such a study. The study found that rats exposed to aspartame starting at 8 weeks of age, and continuing throughout their lives, developed leukemias, lymphomas, and kidney tumors. In 2007, the same researchers published a follow-up study that exposed rats to aspartame beginning in the womb and continuing throughout their lives. It found that aspartame caused lymphomas, in addition to mammary (breast) cancers. In 2010, the group exposed test mice to aspartame while they were still in the womb again, and made the startling discovery that the mice developed liver cancers and lung cancers too.
The most respected long-term study of aspartame in humans, Consumption of Artificial Sweetener -- and Sugar-Containing Soda and Risk of Lymphoma and Leukemia in Men and Women, was conducted by researchers at the Harvard School of Public Health. It provided evidence that aspartame causes an increased risk of cancer in men, but this effect was not mirrored in women. This finding might be due to the fact that men have higher levels of an enzyme that converts the methanol from aspartame metabolisis into formaldehyde, a carcinogen. The cancers that were observed in the Harvard study mimicked the results that were seen elsewhere in animal studies.
There is strong evidence connecting aspartame to Parkinson's Disease. Aspartate is one of the main components that is released when aspartame is metabolized, and it directly effects the N-methyl-D-aspartate receptors inside the brain. NMDA receptor excitotoxicity is associated with Parkinson's disease. Regular intake of aspartame damages these receptors, and this sometimes leads to Parkinson's disease. The 2007 study entitled, Aspartame Decreases Evoked Extracellular Dopamine Levels in the Rat Brain, by Muskingum College in Ohio, showed that aspartame reduces dopamine levels in the brains of rats. When dopamine is dramatically reduced, there is a neurological decline matching that which is seen in those with Parkinson's disease. In 2001, the Norwegian University of Science published a research study verifying that aspartame is both an excitotoxin and a neurotoxin that is particularly unsafe for children.
Saccharin (Sweet'N Low)
Saccharin is the oldest of the artificial sweeteners. The Monsanto company was founded in 1901 to produce and market saccharin, so it was the company's flagship product. It was discovered accidentally in 1879 by the chemist, Constantin Fahlberg, who was researching coal tar derivatives. Saccharin is the alias that he gave to his discovery. The official chemical name for it is benzoic sulfimide. The "benzoic" part indicates the presence of benzene. In other words, paint stripper. It is one of the most potent carcinogens, which is especially known for causing leukemias, liver damage, and DNA damage. In the 1960's and 1970's, a growing diet food industry embraced the use of saccharin, which led to its widespread usage. It was ironically promoted for the sake of health, since it eliminated the purported dangers of real sugar. As early as 1977, it was discovered that this chemical is quite dangerous. The Food and Drug Administration swiftly moved to get it banned, in light of its propensity for causing cancers. Instead, the U.S. Congress passed the Saccharin Study and Labeling Act, which allowed saccharin to be sold with the warning label, "Use of this product may be hazardous to your health. This product contains saccharin which has been determined to cause cancer in laboratory animals." The U.S. Congress actually passed a law to specifically stop the F.D.A. from banning saccharin, so it still remains on the market after decades. Canada immediately banned saccharin, however.
In 1997, the diet industry began seeking permission to remove the warning label from saccharin products. As a Christmas present to the chemical industry, the U.S. Congress passed another law specific to helping it on December 21st, 2000, wherein it removed the mandatory warning label requirement for saccharin. Around the same time, the Canadian Government unlisted saccharin as a carcinogen too. The revisionist history now states that the original studies which proved saccharin's dangers were flawed, because the biological mechanism that caused cancers in rats may not necessarily appear in humans. Even if this were true (and it is not), it ignores the fact that numerous studies since have proven the human cancer risk. The link between saccharin and kidney failure in humans has also been repeatedly established, as well as the tendency of saccharin to cause bladder cancers. Infants who are fed saccharin develop muscular disorders, alongside irritability, and brain cancers.
Incredibly, the chemical industry is now attempting to get saccharin (Sweet'N Low) classified as a drug for the treatment of cancerous brain tumors, which it is known to cause. The evaluation of saccharin as an anti-cancer drug means that the chemical industry has implicitly admitted that saccharin is not just a benign sweetener, for only poisons are used as standard cancer treatments. To make their case, they are now even admitting that it deactivates proteins within the body during this type of cancer "therapy". This comes after a century of denials about its effects upon the human body and the claims of its benign nature.
Acesulfame Potassium (Acesulfame-K)
As with most chemical sweeteners, acesulfame potassium was approved based solely upon safety data that was provided by its manufacturer (Hoechst). The manufacturer's own studies showed the tendency of acesulfame potassium to induce cancers. The N.I.H.'s National Institute on Aging published a study in August 2013, which showed that the routine use of acesulfame potassium causes neurological disorders, such as reduced memory. The Center for Science in the Public Interest petitioned the F.D.A. in 1996 to not approve acesulfame potassium for use in soft drinks until independent research had been done. The request was ignored. Acetoacetamide, a breakdown product of metabolized acesulfame potassium, causes thyroid disease in mammals.
Acesulfame potassium is rarely used alone. It is most often combined with sucralose (Splenda). It is reported to have an unpleasant chemical aftertaste when it is used alone, so its aftertaste is masked by sucralose.